Qatar’s Foreign Ministry spokesman, Majed al-Ansari, announced late Wednesday on X that the shipment had crossed into Gaza, without saying when or how the medicine would be distributed.

“Over the past few hours, medicine & aid entered the Gaza Strip, in implementation of the agreement announced yesterday for the benefit of civilians in the Strip, including hostages,” he wrote.

A senior Hamas official said that for every box provided for the hostages, 1,000 boxes of medicine would be sent in for Palestinians. The deal also includes the delivery of humanitarian aid to Gaza residents.

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The agreement came 100 days into the conflict and as Palestinian militants are still putting up resistance across Gaza in the face of one of the deadliest military campaigns in recent history.

More than 24,000 Palestinians have been killed. Some 85 per cent of the narrow coastal territory’s 2.3 million people have fled their homes, and the United Nations says a quarter of the population is starving.

Israel has vowed to dismantle Hamas to ensure it can never repeat an attack like the one on October 7 that triggered the war. Militants burst through Israel’s border defences and stormed through several communities that day, killing some 1,200 people, mostly civilians, and capturing around 250.

Israel also has promised to win the return of the hostages still held inside Gaza.

Hamas has said it will not release any more hostages until there is a permanent ceasefire, something Israel and the United States, its top ally, have ruled out.

The last deal in late November between Israel and Hamas brought a temporary truce in exchange for the release of more than 100 hostages, mostly women and children, as well as freedom for dozens of Palestinians imprisoned by Israel.

A Qatari official said the medicine would be delivered to the hostages by the Health Ministry in the Hamas-run territory.

It was not immediately clear when the drugs would be delivered, or how the handover would be verified. The official spoke on condition of anonymity because he was discussing behind-the-scenes diplomatic efforts.

France said it took months to organise the shipment of the medicines. Qatar, which has long served as a mediator with Hamas, helped broker the deal that will provide three months’ worth of medication for chronic illnesses for 45 of the hostages, as well as other medicine and vitamins. Several older men are among the remaining hostages.

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Moussa Abu Marzouk, a senior Hamas official, said in a post on X that the International Committee of the Red Cross will deliver all the medicines, including the ones destined for the hostages, to hospitals serving all parts of Gaza. The ICRC declined to comment.

Senior UN officials have warned that Gaza faces widespread famine and disease if more aid is not allowed in.

Israel completely sealed off Gaza after Hamas’ October 7 attack and only relented under US pressure. It says there are now no limits on the entry of humanitarian aid and that UN agencies could reduce the delays by providing more workers and trucks.

But UN officials say aid delivery is hobbled by the opening of too few border crossings, a slow vetting process and fighting throughout the territory – all of which is largely under Israel’s control.

Israel said at the start of the year that it had largely defeated Hamas in northern Gaza and would scale back operations there, focusing on dense urban areas in the centre and south of the territory.

Additional Israeli forces withdrew from Gaza on Monday, but there has been little apparent letup in strikes, with scores of Palestinians killed every day.

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Gaza’s Health Ministry said Wednesday that 163 bodies were brought to the territory’s remaining functioning hospitals in the past 24 hours, as well as 350 wounded people. The update brought the war’s overall death toll in Gaza to 24,448, with over 60,000 wounded.

The ministry said many other dead and wounded are trapped under rubble or unreachable because of the fighting.

The ministry does not differentiate between civilian and combatant deaths but says around two-thirds of those killed were women and children.

Israel blames the high civilian death toll on Hamas because it fights in dense residential areas. Israel says its forces have killed roughly 9,000 militants, without providing evidence, and that 192 of its own soldiers have been killed since the Gaza ground offensive began.

Militants are still fighting in all parts of the territory, and Israel appears no closer to freeing the remaining hostages. The deaths of two more hostages were confirmed Tuesday after Hamas said they were killed in Israeli air strikes.

Tensions are soaring in the occupied West Bank, where Israeli forces have conducted near-daily arrest raids that often trigger shoot-outs with Palestinian militants.

Israeli forces killed at least 10 Palestinians Wednesday in the territory, including five in the urban Balata refugee camp in the north, the military said. Among that group was a senior militant whom the military said was responsible for militant infrastructure and was allegedly involved in recent attacks against Israelis.

Five Palestinians were killed in an Israeli strike in Tulkarem, the Palestinian Health Ministry said. The military said it targeted a group of militants who had opened fire and were throwing explosives at Israeli soldiers.

Over 360 Palestinians have been killed in the West Bank since October 7.

The Middle East has seen a dizzying array of strikes and counterstrikes from northern Iraq to the Red Sea and from southern Lebanon to Pakistan.

A bomb-carrying drone launched from a Houthi-controlled area hit a US-owned ship in the Gulf of Aden Wednesday.

Iran has struck what it described as an Israeli spy headquarters in northern Iraq and anti-Iran militants in Pakistan and Syria. Israel and Lebanon’s Hezbollah have escalated the intensity of their fighting across the border, raising fears of another war.